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[hepar + -in] A parenteral anticoagulant drug with a faster onset than warfarin or its derivatives. It is composed of polysaccharides that inhibit coagulation by forming an antithrombin that prevents conversion of prothrombin to thrombin and by preventing liberation of thromboplastin from platelets. Because heparin is poorly absorbed from the gastrointestinal tract, it is usually administered intravenously or subcutaneously as a sodium or calcium salt.
USES Heparin is used as an anticoagulant to prevent and treat thrombosis and embolism. It is an important agent in the management of acute coronary syndromes, e.g., unstable angina pectoris or acute myocardial infarction. Because heparin compounds are too large to cross the placental barrier, they are the preferred anticoagulants in pregnant women. The antagonist for an overdose is protamine sulfate. The most common side effect of heparin is abnormal bleeding.
Venes, Donald, editor. "Heparin." Taber's Medical Dictionary, 23rd ed., F.A. Davis Company, 2017. Taber's Online, www.tabers.com/tabersonline/view/Tabers-Dictionary/751430/all/low_molecular_weight_heparin.
Heparin. In: Venes D, ed. Taber's Medical Dictionary. 23rd ed. F.A. Davis Company; 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/751430/all/low_molecular_weight_heparin. Accessed December 7, 2019.
Heparin. (2017). In Venes, D. (Ed.), Taber's Medical Dictionary. Available from https://www.tabers.com/tabersonline/view/Tabers-Dictionary/751430/all/low_molecular_weight_heparin
Heparin [Internet]. In: Venes D, editors. Taber's Medical Dictionary. F.A. Davis Company; 2017. [cited 2019 December 07]. Available from: https://www.tabers.com/tabersonline/view/Tabers-Dictionary/751430/all/low_molecular_weight_heparin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - heparin
ID - 751430
ED - Venes,Donald,
BT - Taber's Medical Dictionary
UR - https://www.tabers.com/tabersonline/view/Tabers-Dictionary/751430/all/low_molecular_weight_heparin
PB - F.A. Davis Company
ET - 23
DB - Taber's Online
DP - Unbound Medicine