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[mastocyte + -osis]
Any of several rare disorders in which there is proliferation of normal mast cells systemically or on the skin. The lesions on the skin are called urticaria pigmentosa.
SEE: urticaria pigmentosa
Systemic mastocytosis is marked by infiltration of mast cells into the bone marrow, abdominal organs, and lymph nodes. Many of the signs and symptoms of this illness are due to the mast cells releasing granules containing histamine, prostaglandins, and arachidonic metabolites.
SEE: Darier sign under SEE: Darier, Ferdinand Jean for illus