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[mucopolysaccharide + -osis] ABBR: MPS Any of a group of inherited disorders characterized by a deficiency of enzymes that are essential for the degradation of the mucopolysaccharides heparan sulfate, dermatan sulfate, and keratan sulfate. These chemicals are excreted in excess quantities in the urine, and they usually accumulate in macrophages, the central nervous system, endothelial cells, intimal smooth muscle cells, and fibroblasts throughout the body. Clinical changes are not usually apparent at birth, but the inherited defect can be diagnosed prior to birth by culturing amniotic fluid cells and testing them for specific enzyme activity. After birth, the conditions may be diagnosed by testing cultured skin fibroblasts for specific enzymes. Some MPS may be treated with bone marrow transplantation.
Venes, Donald, editor. "Mucopolysaccharidosis." Taber's Medical Dictionary, 23rd ed., F.A. Davis Company, 2017. Taber's Online, www.tabers.com/tabersonline/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV.
Mucopolysaccharidosis. In: Venes D, ed. Taber's Medical Dictionary. 23rd ed. F.A. Davis Company; 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV. Accessed October 14, 2019.
Mucopolysaccharidosis. (2017). In Venes, D. (Ed.), Taber's Medical Dictionary. Available from https://www.tabers.com/tabersonline/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV
Mucopolysaccharidosis [Internet]. In: Venes D, editors. Taber's Medical Dictionary. F.A. Davis Company; 2017. [cited 2019 October 14]. Available from: https://www.tabers.com/tabersonline/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - mucopolysaccharidosis
ID - 729556
ED - Venes,Donald,
BT - Taber's Medical Dictionary
UR - https://www.tabers.com/tabersonline/view/Tabers-Dictionary/729556/all/mucopolysaccharidosis_IV
PB - F.A. Davis Company
ET - 23
DB - Taber's Online
DP - Unbound Medicine