Substance
Amphetamines and amphetamine-like agents

Pathology
Excessive stimulation of the CNS and of peripheral alpha and beta receptor sites.

Symptoms
Excitement, restlessness, tremors, hyperactive reflexes, nausea, vomiting, diarrhea, palpitations, arrhythmias, hypertension, hyperthermia, dehydration, mydriasis, agitation, seizures, coma, death.

Emergency Measures
Supportive care including airway maintenance and cardiac monitoring; administration of activated charcoal and a cathartic; cooling measures for hyperthermia; benzodiazepines for seizures; vasodilators and beta-adrenergic blockers.

Comments
Toxicity can occur with slightly higher than therapeutic doses. Tolerance can readily develop with repeated use.