A drug (such as probenecid or sulfinpyrazone) that increases the urinary excretion of uric acid by blocking renal tubular absorption, thereby reducing the concentration of uric acid in the blood. It is used to treat gout.

PATIENT CARE
Probenecid and sulfinpyrazones are used to treat gout. Side effects of both include headache, gastrointestinal upset, epigastric pain, kidney stone formation, and peptic ulceration. These drugs should be avoided by patients with diminished renal function. Any uricosuric agent should be taken with milk, food, or antacids to reduce gastric distress. Patients should drink large volumes of water. Sodium bicarbonate (or potassium citrate) is prescribed simultaneously with these agents to alkalinize urine and keep uric acid crystals in solution.