Coombs test


[R.R.A. Coombs, Brit. immunologist, 1921-2006]
A laboratory test for the presence of antibodies, usually blood type antibodies, in serum. The patient's serum is incubated with red blood cells (RBCs) with known antigenic markers; if antibodies to the antigen are present in the serum, they bind with the RBCs. When antihuman globulin is added, RBC clumping (agglutination) occurs. The test is used for crossmatching blood before transfusions to ensure that no antigen-antibody reactions will occur and to test for the presence of specific antibodies to RBCs.

Coombs test is a sample topic from the Taber's Medical Dictionary.

To view other topics, please or .

Taber’s Cyclopedic Medical Dictionary 24th Edition Online + App from F.A. Davis and Unbound Medicine. Find 75,000 medical and nursing definitions. Download to iPhone, iPad, and Android. .